Orlistat reversibly blocks gastrointestinal lipases. It inhibits the absorption of dietary fats by forming a covalent bond with the active serine residue site of the gastric and pancreatic lipases within the lumen of the stomach and small intestine, thus preventing the hydrolysis of dietary fat in the form of triglycerides into absorbable free fatty acids and monoglycerides.
Should be taken with food. Take immediately before or during or up to 1 hr after each main meal. If a meal is missed or contains no fat, the dose may be omitted.
Cholestasis and chronic malabsorption syndrome. Pregnancy and lactation.
Patients with diabetes, thyroid disease, epilepsy, anorexia nervosa, bulimia, history of hyperoxaluria or Ca oxalate nephrolithiasis. Renal and hepatic impairment.